Endoplasmic Reticulum Stress in Health and Disease (Paperback)
  • Endoplasmic Reticulum Stress in Health and Disease (Paperback)
zoom

Endoplasmic Reticulum Stress in Health and Disease (Paperback)

(editor), (editor)
£129.99
Paperback 452 Pages / Published: 20/09/2014
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as `ER stress'. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

Publisher: Springer
ISBN: 9789400792517
Number of pages: 452
Weight: 700 g
Dimensions: 235 x 155 x 24 mm
Edition: 2012 ed.

You may also be interested in...

The Lock and Key of Medicine
Added to basket
In Defense of Self
Added to basket
Immunology
Added to basket
£42.99
Paperback
The Salicylate Handbook
Added to basket
Immunology at a Glance
Added to basket
BIOS Instant Notes in Immunology
Added to basket
The Autoimmune Solution
Added to basket
Immunology
Added to basket
£46.99
Paperback
Essentials of Clinical Immunology
Added to basket
Schaum's Outline of Immunology
Added to basket
Coeliac Disease
Added to basket
£8.99
Paperback
Basic and Clinical Immunology
Added to basket
Oxford Handbook of Respiratory Medicine
Added to basket
Allergy
Added to basket
£16.95
Paperback
Histamine Intolerance
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.