Visit our Christmas Gift Finder
Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease - Advances in Experimental Medicine and Biology 517 (Paperback)
  • Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease - Advances in Experimental Medicine and Biology 517 (Paperback)
zoom

Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease - Advances in Experimental Medicine and Biology 517 (Paperback)

(author)
£109.99
Paperback 148 Pages / Published: 05/11/2012
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
Parkinson's disease, a degenerative brain disorder, affects an estimated 0.25-0.50% of the population. Symptoms result from neuronal degeneration in the nigrostriatal dopaminergic pathway and include tremor, rigidity and gradual slow- ness of spontaneous movement. The cause of Parkinson's disease is only partially understood; both environmental factors and a genetic predisposition have been im- plicated in its etiopathogenesis. Neural transplantation is being used experimentally for providing an alternative biological source of dopamine both in animal studies and in experimental clinical trials. This book is the result of 15 years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse, a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. The weaver mouse constitutes the only available laboratory model with a chronic progressive disease that mimics Parkinsonism. The other two models currently used to investigate dopaminergic mechanisms rely on the use of the neurotoxins- hydroxydopamine and methylphenyltetrahydropyridine for the selective removal of dopaminergic neurons from an otherwise healthy organism. Structural and functional aspects of transplantation of mesencephalic dopamin- ergic grafts into the striatum of weaver mice are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor neuron survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopam- ine uptake function and receptor binding, gene expression of several structural and neurotransmitter-receptor related molecules, the levels of striatal amino acid receptors, and the behavioral effects of unilateral and bilateral neuronal transplantations.

Publisher: Springer-Verlag New York Inc.
ISBN: 9781461352013
Number of pages: 148
Weight: 260 g
Dimensions: 235 x 155 x 9 mm
Edition: Softcover reprint of the original 1st ed. 200

You may also be interested in...

Incognito
Added to basket
£9.99
Paperback
Headhunters
Added to basket
£11.99
Paperback
30-Second Brain
Added to basket
High Price
Added to basket
£9.99
Paperback
Descartes' Error
Added to basket
£10.99
Paperback
Mind Change
Added to basket
£9.99
Paperback
Murderous Minds
Added to basket
£10.99
Paperback
The Autistic Brain
Added to basket
This Idea Must Die
Added to basket
£11.99
Paperback
The Brain: A Very Short Introduction
Added to basket
The Brain Book
Added to basket
£25.00
Hardback
The Private Life of the Brain
Added to basket
Headhunters
Added to basket
£25.00
Hardback
The Tale of the Duelling Neurosurgeons
Added to basket
The Domesticated Brain
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.