DNA Conjugates and Sensors - RSC Biomolecular Sciences (Hardback)Tom Brown (editor), K. R. Fox (editor), Duncan Graham (author of contributions), Peter G. Stockley (author of contributions), Makoto Komiyama (author of contributions), David Klenerman (author of contributions), Patrick Hrdlicka (author of contributions), Yingfu Li (author of contributions), Andrew Ellington (author of contributions), Souvik Maiti (author of contributions)
Hardback 316 Pages / Published: 18/10/2012
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Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.
Publisher: Royal Society of Chemistry
Number of pages: 316
Weight: 658 g
Dimensions: 234 x 156 x 24 mm
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