Dialysis-related amyloidosis is a freequent complication encountered in patients receiving long-term haemodialysis. This book presents evidence on the possible role of beta2-microglobulin modified with advanced glycation end products (AGE) in the pathogenesis of the disease. The first of the three sections investigates the structure of AGE-modified protein, its formation mechanisms and its biological activity. The book reveals that AGE-modified beta2-microglobulin has a chemotactic effect on monocytes, and stimulates macrophages to secrete interleuken 1beta, interleuken 6 and TNFalpha. In other sections, the factors causing dialysis related amyloidosis are examined and the effectiveness of various haemo-purification methods in alleviating osteoarthropathy are assessed.
Publisher: S Karger AG
Number of pages: 176
Weight: 530 g
Dimensions: 216 x 138 mm
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