Controlled Clinical Trials in Neurological Disease - Foundations of Neurology 1 (Paperback)
  • Controlled Clinical Trials in Neurological Disease - Foundations of Neurology 1 (Paperback)
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Controlled Clinical Trials in Neurological Disease - Foundations of Neurology 1 (Paperback)

(editor), (editor)
£249.99
Paperback 440 Pages / Published: 01/10/2011
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The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im- portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru- ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and their statistical colleagues: this is the controlled clinical trial. During the past two decades, the evaluation of clinical approaches to pre- vention and therapy has become particularly important to clinicians concerned with nervous system dysfunction. There has been and continues to be an explosion of information from the basic neurosciences and from the applica- tion of biotechnology to the nervous system.

Publisher: Springer-Verlag New York Inc.
ISBN: 9781461288046
Number of pages: 440
Weight: 712 g
Dimensions: 235 x 155 x 24 mm
Edition: Softcover reprint of the original 1st ed. 199


MEDIA REVIEWS
`Cet ouvrage, redigee par de nombreux experts et d'une maniere fort critique, est certainement tres precieux. Il merite d'etre lu et medite.'
Acta Neurologica, 90, 1990

` ... for any serious researcher. The book is recommended for all health care professionals who have an interest in neurological neurosurgical or neurorehabilitative research.'
Brain Injury, 7:1

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