Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors (Hardback)Eric Wickstrom (editor)
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Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
furnishes a historical overview of genetic therapy
highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors
offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials
discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications
illustrates for new practitioners how each stage of genetic therapy is developed
details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis
includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy
and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.
Publisher: Taylor & Francis Inc
Number of pages: 448
Weight: 953 g
Dimensions: 234 x 156 x 25 mm
This volume clearly demonstrates that genetic therapy is underway, and that the efforts described are soundly based in rationale and feasibility...Our increasing understanding of the mechanisms of conversion of the genetic code into function indicate that gene based therapy will become a mainstay of disease control in the 21st century.
"-O. Michael Colvin, Duke University Medical Center, Durham, North Carolina
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