
Clinical Epigenetics (Paperback)
Luke B. Hesson (editor), Antonia L. Pritchard (editor)- We can order this from the publisher
In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories.
The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
Publisher: Springer Verlag, Singapore
ISBN: 9789811389603
Number of pages: 265
Weight: 514 g
Dimensions: 235 x 155 mm
Edition: 1st ed. 2019
You may also be interested in...
Please sign in to write a review
Sign In / Register
Sign In
Download the Waterstones App
Would you like to proceed to the App store to download the Waterstones App?
Click & Collect
Alternatively, for multiple items you may find it easier to add to basket, then pay online and collect in as little as 2 hours, subject to availability.