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Chiral Separations: Methods and Protocols - Methods in Molecular Biology 243 (Paperback)
  • Chiral Separations: Methods and Protocols - Methods in Molecular Biology 243 (Paperback)

Chiral Separations: Methods and Protocols - Methods in Molecular Biology 243 (Paperback)

(editor), (editor)
Paperback 432 Pages / Published: 16/12/2010
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Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism. The admin- tration of pure, pharmacologically active enantiomers is therefore of great importance. The ideal way to get to pure enantiomers would be by enantioselective synthesis. However, this approach is usually expensive and not often practicable. Usually, the racemates are obtained in a synthesis, and the separation of the enantiomers on a preparative scale is necessary. On the other hand, there is also a great demand for methods of enantiomer separation on an analytical scale for controlling synthesis, checking for racemization p- cesses, controlling enantiomeric purity, and for pharmacokinetic studies. C- ventional methods for enantiomer separation on a preparative scale are fractionated crystallization, the formation of diastereomeric pairs followed by repeated recrystallization, and enzymatic procedures. In recent years, ch- matographic methods such as gas chromatography and, especially, liquid ch- matography have attracted increasing interest for chiral separation, both on analytical and preparative scales.

Publisher: Humana Press Inc.
ISBN: 9781617373909
Number of pages: 432
Weight: 756 g
Dimensions: 229 x 152 mm
Edition: Softcover reprint of hardcover 1st ed. 2004

"It is an excellent book, and can be recommended for every laboratory involved in the synthesis and analysis of chiral compounds. Moreover, the editors have succeeded in getting internationally known leading experts to write the contributions." -Angewandte Chemie

"...will undoubtedly be of value to those who need to find useful ways to carry out such separations." -Journal of Medicinal Chemistry

"...this book is a useful compendium of chiral methods and will be of use to many workers in the field." - Biomed Chronatogr

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