Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Publisher: Humana Press Inc.
Number of pages: 512
Weight: 2690 g
Dimensions: 254 x 170 x 28 mm
Edition: 2000 ed.
"This book is an elegant survey of primate and nonprimate models for the most important of the CNS diseases, examining the prospects of treatment from various (slightly) promising drug therapies to the newest forms of fetal-tissue grafting. But more than that, the editors have compiled a paradigmatic study on the critical need for animal experimentation for the elucidation and treatment of human disease. Each chapter points out how animal models provided the only nonsuperficial insight available on various CNS syndromes, and perhaps equally important, how animals served as models for verification of theories and as test subjects for potential treatments. "- Modern Drug Discovery
"...the contributions contained in this monograph represent a serious attempt by many of the most important researchers in neuroscience to critically assess the most useful animal models in development today... this is an excellent volume which will be an essential reading for all experimental neuropharmacologists and a constant source of reference to both clinical and basic psychopharmacologists. The editors are to be congratulated for gathering together such an authoritative group of authors who have explained their research interests in an easily accessible way." - Human Phychopharmacology