• Sign In
  • Help
  • My Basket0
Cell Migration in Inflammation and Immunity: Methods and Protocols - Methods in Molecular Biology 239 (Paperback)
  • Cell Migration in Inflammation and Immunity: Methods and Protocols - Methods in Molecular Biology 239 (Paperback)
zoom

Cell Migration in Inflammation and Immunity: Methods and Protocols - Methods in Molecular Biology 239 (Paperback)

(editor), (editor)
£127.50
Paperback 277 Pages / Published: 10/11/2010
  • We can order this

Usually despatched within 3 weeks

  • This item has been added to your basket

Check Marketplace availability

Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of leukocyte trafficking in basal and inflammatory conditions to the regulation of hema- poiesis, angiogenesis, tissue architecture, and organogenesis. The basis for such diversified activities rests, on one hand, upon the ubiquitous nature of chemokine production and chemokine receptor expression. Virtually every cell type can produce chemokines and expresses a unique combination of chemokine receptors. On the other hand, chemokine receptors make use of a flexible and complex network of intracellular signaling machineries that can regulate a variety of cellular functions ranging from cell migration, growth, and differentiation to death. As knowledge of the size of chemokine and chemokine receptor families rapidly reaches completeness, much is still to be uncovered in terms of fu- tional architecture of the chemokine system. The disparity between the large number of chemokines and that smaller number of receptors is balanced by the promiscuity in ligand-receptor interactions, with multiple chemokines binding to the same receptor and several chemokines binding to more than one receptor.

Publisher: Humana Press Inc.
ISBN: 9781617373572
Number of pages: 277
Weight: 433 g
Dimensions: 229 x 152 x 16 mm
Edition: Softcover reprint of hardcover 1st ed. 2003

You may also be interested in...

Basic and Clinical Immunology
Added to basket
Immunology, second edition
Added to basket
BIOS Instant Notes in Immunology
Added to basket
Oxford Handbook of Medical Sciences
Added to basket
£29.99
Part-work (fascículo)
Boosting Your Immunity for Dummies
Added to basket
Ultimate Allergy-Free Cookbook
Added to basket
The Salicylate Handbook
Added to basket
Mind, Immunity and Health
Added to basket
The Immune System
Added to basket
£56.00
Paperback
Tumor Immunology
Added to basket
£36.99
Paperback
Immunology
Added to basket
£18.99
Paperback
Oxford Handbook of Clinical Immunology and Allergy
Added to basket
Coeliac Disease
Added to basket
£8.99
Paperback
Schaum's Outline of Immunology
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.