• Sign In
  • Help
  • My Basket0
The books you love, the emails you want
Opt in by 25 May or you'll stop hearing from us
REVIEW NOW
Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications - Subcellular Biochemistry 75 (Hardback)
  • Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications - Subcellular Biochemistry 75 (Hardback)
zoom

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications - Subcellular Biochemistry 75 (Hardback)

(editor), (editor)
£139.99
Hardback 430 Pages / Published: 05/11/2013
  • We can order this

Usually despatched within 3 weeks

  • This item has been added to your basket

Check Marketplace availability

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

Publisher: Springer
ISBN: 9789400773585
Number of pages: 430
Weight: 876 g
Dimensions: 235 x 155 x 25 mm
Edition: 2014 ed.

You may also be interested in...

Oxford Handbook of Medical Sciences
Added to basket
£29.99
Part-work (fascículo)
Muscular Dystrophy
Added to basket
The Biology of Cancer
Added to basket
Genomic Medicine
Added to basket
£24.50
Paperback
Epigenetics
Added to basket
£12.99
Paperback
Medical Genetics at a Glance
Added to basket
Genetics, revised edition
Added to basket
The Violinist's Thumb
Added to basket
£9.99
Paperback
Epigenetics
Added to basket
£14.99
Paperback
Principles of Psychiatric Genetics
Added to basket
Screening
Added to basket
£49.49
Paperback
Inheritance
Added to basket
£18.99
Hardback
Genes: A Very Short Introduction
Added to basket
Monkeyluv
Added to basket
£9.99
Paperback

Reviews

Please sign in to write a review

Your review has been submitted successfully.