Cancer Stem Cells: Philosophy and Therapies (Hardback)
  • Cancer Stem Cells: Philosophy and Therapies (Hardback)
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Cancer Stem Cells: Philosophy and Therapies (Hardback)

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£36.95
Hardback 272 Pages
Published: 01/06/2016
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An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

Rather than treat cancer by aggressively trying to eliminate all cancerous cells—with harmful side effects for patients—CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells—the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation.

To date, researchers have not agreed on the defining feature of CSCs—their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell’s relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

Publisher: Harvard University Press
ISBN: 9780674088740
Number of pages: 272
Dimensions: 235 x 156 mm


MEDIA REVIEWS

Laplane places us right in the center of an urgently important discussion of cancer stem cells and the therapies that should accompany different theories. Her fresh philosophical perspective introduces us to a science in process, where the outcome is unknown and even the terms of debate remain contested. - Jane Maienschein, author of Embryos under the Microscope

If you had doubts about the utility of philosophy for science, read this book. Its lucid exploration of stem cells will convince you that even cancer therapy can benefit from the lights of philosophy. - Michel Morange, author of A History of Molecular Biology

Builds a much broader framework for understanding the biology of stem cells of all types…Laplane’s rigorous analyses unveil deep semantic and conceptual problems in the field…Laplane’s stemness framework should be of great value…A philosopher may indeed have straightened out the stem-cell field. - Hans Clever, Nature

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