Bioisosteres in Medicinal Chemistry - Methods and Principles in Medicinal Chemistry (Hardback)
  • Bioisosteres in Medicinal Chemistry - Methods and Principles in Medicinal Chemistry (Hardback)
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Bioisosteres in Medicinal Chemistry - Methods and Principles in Medicinal Chemistry (Hardback)

(editor), (series editor), (series editor), (series editor)
£120.00
Hardback 256 Pages / Published: 22/08/2012
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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Publisher: Wiley-VCH Verlag GmbH
ISBN: 9783527330157
Number of pages: 256
Weight: 624 g
Dimensions: 244 x 175 x 17 mm

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