Visit our Christmas Gift Finder
Click & Collect from 2 Hours*
Free Delivery to UK Shops
Free UK Standard Delivery On all orders £20 and over Free Delivery to UK Shops Local shops and expert booksellers nationwide Free Click & Collect to UK shops From 2 hours of your order*
Bioinformatics for Systems Biology (Paperback)
  • Bioinformatics for Systems Biology (Paperback)
zoom

Bioinformatics for Systems Biology (Paperback)

(editor)
£139.99
Paperback 639 Pages / Published: 23/08/2016
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
With the completion of the human genome project, followed by the rise in high-throughput technologies like the various microarray and now high throughput genomic sequencing platforms, weexperiencedthebirthofSystemsBiologyafteritslonggestation. Thisrevolutionis markedbyachangeintheresearchparadigmfromthesinglesmall-scaleexperiment, i. e., following thechangeofacomponentinamulticomponentsystem, toonethatattemptstosimultaneously monitorthechangeoftensofthousandsofmoleculeswithinthisbody. Thisclearlynecessitatesthe unparalleleduseofproject-specificinformatictools, which, todate, requiresanunprecedentedlevel ofdevelopmenttocollect, manageandminethedataforinterestingassociations. Tobegintounderstandthisinformationwenowrelyonstatisticalanalysistoaidinourselection ofthefruitfromthetree. However, thisoftentakesusonajourneyintoanewfieldforwhichweare notyetprepared. SamuelJohnson(1709-1784)foreshadowedthedilemmawewouldfaceand characterizeditasfollows: ''Knowledgeisoftwokinds. Weknowasubjectourselves, orweknow wherewecanfindinformationonit. ''Itisforthelatterthatweroutinelyturntotheliterature. The rateofgrowthoftheliteratureparallelsthatofsequencingdataandthearraydataplacingan almostimpossibletaskbeforeeachinvestigator. Topartiallyeasethisburdenweareagainturning towardsdevelopinginformaticaidsthatminetheliteratureanddatatodevelopsummariesand associationstodirectlyaddressthequestionsposedandthenewhypothesesthataretobetested. Althoughmoreclearlyarticulated, weagainfacesimilarchallengesasthosetackledduringthe courseofthehumangenomeproject. Itisessentialthatthetrainingofthebiologistandcomput- scientistoccurinaninterdisciplinaryenvironmentofcross-fertilization. Withthisgoalinmindthe textbook''BioinformaticsforSystemsBiology''wasundertaken. WebeginthisexplorationwithPartI, toprovidethecomputerscientistwithanintroductiontothe underlyingprinciplesofcellbiology. ThisisfollowedbyabriefintroductioninPartIIasameansfor thebiologisttobecomefamiliarwithconceptsandthestatisticalanalysisoflargedatasets. PartIII thendescribes, todate, thebestcharacterizeduseofthemicroarrayplatformthatisnowmoving towardswholegenomeanalysis. Withallofthisdata, howdowebeginanalysisforcommonelements guidingtheunderlyingprinciples?ThisisdiscussedinPartIVwhichleadstoPartVandPartVIto test, insilico, therelationshipsonawidescaleinordertoassesstheirapplicability. Upondeveloping theassociations, PartVIIaskshowdoesthisinformationrelatetowhatwasmeasured?Asthesebasic principlesaredevelopedfroman''omics''drivenbiologicalsystemsapproach, theyareappliedin PartVIIItotranslationalmedicine. Anexcellentexampleisthenewterm''personalizedmedicine'' thatisbeginningtoreverberateinclinicalcare. ItistheculminationoftheSystemsBiologyrevolution wheretechnologicaladvancesandcross-fertilizationhavedriventhefieldtomaturetothepoint whereitisbeingincorporatedinatruebench-to-bedsidemanner. Asyoureadthechapters, youwillfindthattheycanstandalone, yetcanbecombinedto emphasizetheintegralroleofinformaticsinSystemsBiology. Mostofthefiguresandtablesarein greyscale. IwouldencourageyoutoviewthosethatbenefitfromcolorontheaccompanyingCD. ThematerialcontainedontheCDprovidesanexcellentsourceofslidesforyourlecturesand presentations. v vi Preface Thechapter-relatedGlossaryandAbbreviationssectionwillassistinfamiliarizingyouwiththe terms. Youwillalsofindtheliteratureandsuggestedreadingsections, includingkeyreferences, veryusefulasyoudelveintothesubjectmatter. Technology, byitsverymeaningimpliesrefinement and change. The informatics appr

Publisher: Humana Press Inc.
ISBN: 9781493956807
Number of pages: 639
Weight: 1663 g
Dimensions: 254 x 178 mm
Edition: Softcover reprint of the original 2nd ed. 200

You may also be interested in...

Giant Molecules
Added to basket
£17.99
Paperback
Lewin's CELLS
Added to basket
£59.99
Hardback
Genetic Analysis
Added to basket
£58.99
Paperback
A Dictionary of Biology
Added to basket
Life from an RNA World
Added to basket
Thrive in Biochemistry and Molecular Biology
Added to basket
The Manga Guide To Molecular Biology
Added to basket
Molecular Evolution
Added to basket
£48.99
Paperback

Please sign in to write a review

Your review has been submitted successfully.