Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones - Springer Theses (Hardback)
  • Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones - Springer Theses (Hardback)
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Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones - Springer Theses (Hardback)

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Hardback 202 Pages / Published: 09/07/2015
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This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

Publisher: Springer International Publishing AG
ISBN: 9783319205434
Number of pages: 202
Weight: 4616 g
Dimensions: 235 x 155 x 14 mm
Edition: 2015 ed.

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