A Practical Guide to Rational Drug Design (Hardback)
  • A Practical Guide to Rational Drug Design (Hardback)
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A Practical Guide to Rational Drug Design (Hardback)

(author)
£145.00
Hardback 292 Pages / Published: 01/10/2015
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This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.

Publisher: Elsevier Science & Technology
ISBN: 9780081000984
Number of pages: 292
Weight: 430 g
Dimensions: 229 x 152 x 18 mm

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