Osteogenesis Imperfecta (eBook): A Translational Approach to Brittle Bone Disease

by Jay R. Shapiro, Peter H. Byers, Francis H. Glorieux, Paul Sponseller

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Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.

OI is a genetic bone disorder. where people are born with defective connective tissue, or without the ability to make it, usually because of a collagen deficiency. Over the past 28 years, the knowledge base in OI has tremendously expanded in parallel with expanded clinical and basic science interest based on technical progress. Young individuals now have DXA scans after a fracture, and treatment for age-related osteoporosis has merged with treatment of OI adults.


  • Incorporates chapters and information on the ethical issues related to OI as will the importance of nutrition in managing the OI child and the OI adult
  • Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI
  • Discusses the role of physical medicine and rehabilitation for OI patients, the current status of OI medical treatment, as well as prospects for genetic engineering in the future
  • Provide a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.
  • Product details

    Published
    06/08/2013

    Publisher
    Academic Press

    ISBN
    9780123977892


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